The enzymic oxidation of pyridoxal by liver aldehyde oxidase
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منابع مشابه
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.
The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where they provide a protective barrier by aiding in the detoxification of ingested nitrogen-containing heterocycles. Isovanillin has been shown to inhibit the metabolism of aromati...
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The selective estrogen receptor modulator, raloxifene, has been demonstrated as a potent uncompetitive inhibitor of human liver aldehyde oxidase-catalyzed oxidation of phthalazine, vanillin, and nicotine-Delta1'(5')-iminium ion, with K(i) values of 0.87 to 1.4 nM. Inhibition was not time-dependent. Raloxifene has also been shown to be a noncompetitive inhibitor of an aldehyde oxidase-catalyzed ...
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In spite of over 40 years of clinical use of 6-mercaptopurine, many aspects of complex pharmacology and metabolism of this drug remain unclear. It is thought that 6-mercaptopurine is oxidized to 6-thiouric acid through 6-thioxanthine or 8-oxo-6-mercaptopurine by one of two molybdenum hydroxylases, xanthine oxidase (XO), however, the role of other molybdenum hydroxylase, aldehyde oxidase (AO), i...
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HUMAN LIVER ALDEHYDE OXIDASE (ALDEHYDE: O(2) oxidoreductase, EC 1.2.3.1) has been purified 60-fold and some of its properties studied. Like aldehyde oxidase from other mammalian species, human liver aldehyde oxidase is an enzyme with dual substrate specificity, possessing the ability to catalyze not only the oxidation of aldehydes to the corresponding carboxylic acids, but also the hydroxylatio...
متن کاملaXeto Aldehyde Dehydrogenase, An Enzyme That Catalyzes the Enzymic Oxidation of Methylglyoxal to Pyruvate*
An enzyme which catalyzes the oxidation of methylglyoxal to pyruvic acid was partially purified from aqueous extracts of sheep liver acetone powders. NAD+ or NADP+ was necessary for the oxidation. Changes in methylglyoxal, pyruvate, and pyridine nucleotide were stoichiometrically equivalent. Of various carbonyl-containing compounds tested, only oc-keto aldehydes were substrates. Enzyme activity...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1951
ISSN: 0306-3283
DOI: 10.1042/bj0480333